Duodenal tropism of SARS-CoV-2 and clinical findings in critically ill COVID-19 patients.

ABSTRACT:

Purpose

Duodenal involvement in COVID-19 is poorly studied. Aim was to describe clinical and histopathological characteristics of critically ill COVID-19 patients suffering from severe duodenitis that causes a significant bleeding and/or gastrointestinal dysmotility.

Methods

In 51 critically ill patients suffering from SARS-CoV-2 pneumonia, severe upper intestinal bleeding and/or gastric feeding intolerance were indications for upper gastrointestinal endoscopy. Duodenitis was diagnosed according to macroscopic signs and mucosal biopsies. Immunohistochemistry was performed to detect viral specific protein and ACE2. In situ hybridization was applied to confirm viral replication.

Results

Nine of 51 critically ill patients (18%) suffering from SARS-CoV-2 pneumonia had dev

SUBMITTER: Neuberger M 

PROVIDER: S-EPMC8857399 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature