A metastasis-on-a-chip approach to explore the sympathetic modulation of breast cancer bone metastasis.

ABSTRACT: Organ-on-a-chip models have emerged as a powerful tool to model cancer metastasis and to decipher specific crosstalk between cancer cells and relevant regulators of this particular niche. Recently, the sympathetic nervous system (SNS) was proposed as an important modulator of breast cancer bone metastasis. However, epidemiological studies concerning the benefits of the SNS targeting drugs on breast cancer survival and recurrence remain controversial. Thus, the role of SNS signaling over bone metastatic cancer cellular processes still requires further clarification. Herein, we present a novel humanized organ-on-a-chip model recapitulating neuro-breast cancer crosstalk in a bone metastatic context. We developed and validated an innovative three-dimensional printing based multi-compartment mi

SUBMITTER: Conceicao F 

PROVIDER: S-EPMC8857466 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature