Fabrication of gelatin-based and Zn²⁺-incorporated composite hydrogel for accelerated infected wound healing.

ABSTRACT: Gelatin-based hydrogels have a broad range of biomedical fields due to their biocompatibility, convenience for chemical modifications, and degradability. However, gelatin-based hydrogels present poor antibacterial ability that hinders their applications in treating infected wound healing. Herein, a series of multifunctional hydrogels (Gel@Zn) were fabricated through free-radical polymerization interaction based on gelatin methacrylate (GelMA) and dopamine methacrylate (DMA), and then immersed them into zinc nitrate solutions based on the metal coordination and ionic bonding interaction. These designed hydrogels wound dressings show strong antibacterial activity against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) by increasing intracellular r

SUBMITTER: Tao B 

PROVIDER: S-EPMC8857474 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature