Redox imbalance induces remodeling of glucose metabolism in Rhipicephalus microplus embryonic cell line.

ABSTRACT: Carbohydrate metabolism not only functions in supplying cellular energy but also has an important role in maintaining physiological homeostasis and in preventing oxidative damage caused by reactive oxygen species. Previously, we showed that arthropod embryonic cell lines have high tolerance to H₂O₂ exposure. Here, we describe that Rhipicephalus microplus tick embryonic cell line (BME26) employs an adaptive glucose metabolism mechanism that confers tolerance to hydrogen peroxide at concentrations too high for other organisms. This adaptive mechanism sustained by glucose metabolism remodeling promotes cell survival and redox balance in BME26 cell line after millimolar H₂O₂ exposure. The present work shows that this tick cell line could tolerate hig

SUBMITTER: Della Noce B 

PROVIDER: S-EPMC8857477 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature