Fucosylation of anti-dsDNA IgG1 correlates with disease activity of treatment-naive systemic lupus erythematosus patients.

ABSTRACT:

Background

Systemic Lupus Erythematosus (SLE) is a complex and heterogeneous autoimmune disease mediated by quantities of autoantibodies in which anti-double-stranded DNA (anti-dsDNA) antibodies are important. Besides, glycosylation is one of the most commonly post-translational modifications of antibodies. The association of anti-dsDNA antibodies glycosylation and SLE disease activity is still unknown.

Methods

We enrolled 101 consecutive treatment-naïve SLE patients with positive anti-dsDNA antibodies from the Department of Rheumatology and Immunology at Ruijin Hospital, Shanghai, between 2017 and 2019. Serum samples were used in this study. We analysed the glycosylation of anti-dsDNA IgG and total IgG subclasses according to systemic lupus erythematosus disease activity in

SUBMITTER: Han J 

PROVIDER: S-EPMC8857559 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature