Modulatory role of prenatal alcohol exposure and adolescent stress on the response to arthritis challenge in adult female rats.

ABSTRACT:

Background

There are known environmental risk factors associated with rheumatoid arthritis; however, less is known regarding how the prenatal environment impacts later-life risk for rheumatoid arthritis. Based on preliminary clinical data suggesting that individuals with fetal alcohol spectrum disorder (FASD) are at higher risk for autoimmune disorders, this study investigated the modulatory impact of prenatal alcohol exposure (PAE) on the inflammatory disease profile in an adjuvant-induced arthritis rat model.

Methods

Pregnant rats received liquid ethanol or control diet throughout gestation. To model the increased exposure to stressors often experienced by individuals with FASD, adolescent offspring were exposed to chronic mild stress (CMS) or remained undisturbed. In adul

SUBMITTER: Bodnar TS 

PROVIDER: S-EPMC8857653 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature