An integrated analysis of the competing endogenous RNA network associated of prognosis of stage I lung adenocarcinoma.

ABSTRACT:

Background

Accumulating evidence indicates that long non-coding RNAs (lncRNAs) are involving in the tumorigenesis and metastasis of lung cancer. The aim of the study is to systematically characterize the lncRNA-associated competing endogenous RNA (ceRNA) network and identify key lncRNAs in the development of stage I lung adenocarcinoma (LUAD).

Methods

Totally, 1,955 DEmRNAs, 165 DEmiRNAs and 1,107 DElncRNAs were obtained in 10 paired normal and LUAD tissues. And a total of 8,912 paired lncRNA-miRNA-mRNA network was constructed. Using the Cancer Genome Atlas (TCGA) dataset, the module of ME turquoise was revealed to be most relevant to the progression of LUAD though Weighted Gene Co-expression Network Analysis (WGCNA).

Results

Of the lncRNAs identified, LINC00639, RP4-

SUBMITTER: Xu Y 

PROVIDER: S-EPMC8857797 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature