Integrated analysis of the prognostic and oncogenic roles of OPN3 in human cancers.

ABSTRACT:

Background

Emerging cell- or tissue-based evidence has demonstrated that opsin 3 (OPN3) mediates a variety of pathological processes affecting tumorigenesis, clinical prognosis, and treatment resistance in some cancers. However, a comprehensive analysis of OPN3 across human cancers is unavailable. Therefore, a pancancer analysis of OPN3 expression was performed and its potential oncogenic roles were explored.

Methods

The expression and characterization of OPN3 were evaluated among 33 tumour types using The Cancer Genome Atlas (TCGA) dataset. Additionally, the OPN3 RNA level and overall survival (OS) in relation to its expression level in 33 cancer types were estimated. Based on the analysis above, 347 samples from 5 types of tumours were collected and detected for the protei

SUBMITTER: Zhang W 

PROVIDER: S-EPMC8857800 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature