Human placental exosomes induce maternal systemic immune tolerance by reprogramming circulating monocytes.

ABSTRACT:

Background

The maternal immune system needs to tolerate the semi-allogeneic fetus in pregnancy. The adaptation occurs locally at the maternal-fetal interface as well as systemically through the maternal circulation. Failure to tolerate the paternal antigens may result in pregnancy complications, such as pregnancy loss and pre-eclampsia. However, the mechanism that regulates maternal immune tolerance, especially at the systemic level, is still an enigma. Here we report that the first-trimester placenta-derived exosomes (pEXOs) contribute to maternal immune tolerance by reprogramming the circulating monocytes.

Results

pEXOs predominantly target monocytes and pEXO-educated monocytes exhibit an immunosuppressive phenotype as demonstrated by reduced expression of marker genes for

SUBMITTER: Bai K 

PROVIDER: S-EPMC8857816 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature