Overexpression of OASL upregulates TET1 to induce aberrant activation of CD4⁺ T cells in systemic sclerosis via IRF1 signaling.

ABSTRACT:

Background

Systemic sclerosis (SSc), an autoimmune disease with unknown etiology and pathogenesis, is characterized by abnormal autoimmunity, vascular dysfunction, and progressive fibrosis of skin and organs. Studies have shown that a key factor in the pathogenesis of SSc is aberrant activation of CD4⁺ T cells. Our previous studies have shown that a global hypomethylation state of CD4⁺ T cells is closely related to aberrant activation. However, the exact mechanism of hypomethylation in CD4+T cells is not yet clear.

Methods

Illumina HiSeq 2500 Platform was used to screen differentially expressed genes and explore the role of OASL, TET1, and IRF1 in the abnormal activation of CD4+T cells in SSc. Finally, double luciferase reporter gene experiments were us

SUBMITTER: Zeng Z 

PROVIDER: S-EPMC8857842 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature