Biology and Clinical Implications of Fecal Occult Blood Test Screen-Detected Colorectal Cancer.

ABSTRACT:

Background

Fecal occult blood test (FOBT)-based screening for colorectal cancer (CRC) reduces mortality, with earlier stage at diagnosis a prominent feature. Other characteristics of FOBT screen-detected cancers and any implications for clinical management have not been well explored.

Methods

We examined a multisite clinical registry to compare the characteristics and outcomes of FOBT screen-detected CRC via the Australian National Bowel Cancer Screening Program (NBCSP), which is offered biennially to individuals aged 50-74 years, and age-matched non-screen-detected CRC in the same registry. All statistical tests were 2-sided. Odds ratios (ORs) were calculated using the Baptista-Pike method, and hazard ratios via the log-rank method.

Results

Of 7153 registry patients

SUBMITTER: Mendis S 

PROVIDER: S-EPMC8857921 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature