Structures of telomerase at several steps of telomere repeat synthesis.

ABSTRACT: Telomerase is unique among the reverse transcriptases in containing a noncoding RNA (known as telomerase RNA (TER)) that includes a short template that is used for the processive synthesis of G-rich telomeric DNA repeats at the 3' ends of most eukaryotic chromosomes¹. Telomerase maintains genomic integrity, and its activity or dysregulation are critical determinants of human longevity, stem cell renewal and cancer progression^2,3. Previous cryo-electron microscopy structures have established the general architecture, protein components and stoichiometries of Tetrahymena and human telomerase, but our understandings of the details of DNA-protein and RNA-protein interactions and of the mechanisms and recruitment involved remain limited^4-6. Here we report cryo-e

SUBMITTER: He Y 

PROVIDER: S-EPMC8857963 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature