Cardiac Troponin I and Risk of Stroke: A Mendelian Randomization Study.

ABSTRACT:

Purpose

Cardiac troponin I (cTnI) is a well-established biomarker for stroke prediction, especially in patients with heart diseases. However, the causal effect of circulating cTnI on stroke remains unclear.

Methods

We employed Mendelian Randomization (MR) analysis to determine the associations between genetically predicted circulating cTnI levels and stroke and its subtypes. Summary-level data for exposure and outcomes were generated from different genome-wide association studies. Single-nucleotide polymorphisms (SNPs) associated with circulating cTnI at genome-wide significance level (P < 5 × 10^-8) were employed as instrumental variables (IVs). We used fixed-effect inverse-variance weighted (IVW) as the main method for pooling MR estimates. Sensitivity analyses a

SUBMITTER: Chen H 

PROVIDER: S-EPMC8858012 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature