Hydroyxurea improves cerebral oxygen saturation in children with sickle cell anemia.

ABSTRACT: Neurologic complications are common in patients with sickle cell anemia (SCA), but conventional tools such as MRI and transcranial Doppler ultrasonography (TCD) do not fully assess cerebrovascular pathology. Cerebral tissue oximetry measures mixed oxygen saturation in the frontal lobes (S_CT O₂ ) and provides early prognostic information about tissue at risk of ischemic injury. Untreated patients with SCA have significantly lower S_CT O₂ than healthy controls that declines with age. Hydroxyurea is effective in preventing many SCA-related complications, but the degree to which it preserves normal neurophysiology is unclear. We analyzed participants enrolled in the Therapeutic Response Evaluation and Adherence Trial (TREAT, NCT02286154), which enroll

SUBMITTER: Karkoska K 

PROVIDER: S-EPMC8858025 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature