Abnormal dynamic ventilation function of COVID-19 survivors detected by pulmonary free-breathing proton MRI.

ABSTRACT:

Objectives

To visualize and quantitatively assess regional lung function of survivors of COVID-19 who were hospitalized using pulmonary free-breathing ¹H MRI.

Methods

A total of 12 healthy volunteers and 27 COVID-19 survivors (62.4 ± 8.1 days between infection and image acquisition) were recruited in this prospective study and performed chest ¹H MRI acquisitions with free tidal breathing. Then, conventional Fourier decomposition ventilation (FD-V) and global fractional ventilation (FV_Global) were analyzed. Besides, a modified PREFUL (mPREFUL) method was developed to adapt to COVID-19 survivors and generate dynamic ventilation maps and parameters. All the ventilation maps and parameters were analyzed using Student's t-test. Pearson's correlati

SUBMITTER: Wang C 

PROVIDER: S-EPMC8858033 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature