SARS-CoV-2 vaccination elicits unconventional IgM specific responses in naive and previously COVID-19-infected individuals.

ABSTRACT:

Background

Currently, evaluation of the IgG antibodies specific for the SARS-CoV-2 Spike protein following vaccination is used worldwide to estimate vaccine response. Limited data are available on vaccine-elicited IgM antibodies and their potential implication in immunity to SARS-CoV-2.

Methods

We performed a longitudinal study to quantify anti-S SARS-CoV-2 IgG and IgM (IgG-S and IgM-S) in health care worker (HCW) recipients of the BNT162b2 vaccine. Samples were collected before administration (T0), at the second dose (T1) and three weeks after T1 (T2). The cohort included 1584 immunologically naïve to SARS-CoV-2 (IN) and 289 with history of previous infection (PI).

Findings

IN showed three patterns of responses: (a) IgG positive/IgM negative (36.1%), (b) coordinated

SUBMITTER: Ruggiero A 

PROVIDER: S-EPMC8858081 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature