Direct Relationship between Interleukin-10 Gene Polymorphism and Hepatocellular Carcinoma Complicated by Direct Acting Antiviral Treatment of Hepatitis C Virus.

ABSTRACT:

Objective

This study aimed to assess the correlation between the genotyping of interleukin-10 (IL-10 polymorphism rs 1800871) and the incidence hepatocellular carcinoma (HCC) among patients with hepatitis C virus (HCV) treated with direct acting antivirals (DAAs).

Method

For 200 patients with HCV infection who completed DAA treatment and followed up for 1 year, IL-10 polymorphism SNP(-819) rs 1800871 analysis was conducted via real time polymerase chain reaction. During the follow-up period, 100 patients who developed HCC were selected and compared with 100 patients who did not develop any complications.

Results

The studied patients were divided into two groups according to the incidence of complications after completion of DAA treatments. During the follow-up, 100 pa

SUBMITTER: Ghanm SE 

PROVIDER: S-EPMC8858249 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature