Stromal Changes are Associated with High P4HA2 Expression in Ductal Carcinoma in Situ of the Breast.

ABSTRACT: Ductal carcinoma in situ (DCIS) of the breast is able to induce stromal changes, which likely reflect the crosstalk between DCIS and its microenvironment. These changes harbor prognostic information, although the interobserver variability of scoring stromal changes is moderate. A more robust evaluation of the DCIS-associated stroma is therefore needed. The aim of this study was to characterize P4HA2 expression, which is involved in collagen biosynthesis, in DCIS and to assess whether P4HA2 expression enables a more robust evaluation of the DCIS-associated stroma compared to histomorphology. This study included 410 patients with DCIS. Stromal changes were scored on hematoxylin/eosin-stained whole slides. P4HA2 expression in DCIS-associated stroma was assessed by whole slide immunohistochemi

SUBMITTER: Agahozo MC 

PROVIDER: S-EPMC8858280 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature