Castration-resistant prostate cancer patient presenting with whole genome doubling with CDK-12 mutation.

ABSTRACT:

Background

The use of whole-genome sequencing in clinical practice has revealed variable genomic characteristics across cancer types, one of which is whole-genome doubling (WGD), which describes the duplication of a complete set of chromosomes. Yet it is relatively rare in prostate cancer and no such case has ever been reported in Japanese patients.

Case presentation

A 54-year-old patient with prostatic adenocarcinoma with bone and lymph node metastases was started on androgen-deprivation therapy. As the prostate cancer turned castration-resistant, multimodal therapies including taxane- and platinum-based chemotherapy, androgen-receptor antagonist inhibitors, radiotherapy and radium-233 were introduced. Good controls of serum prostate-specific antigen (PSA) level and bone me

SUBMITTER: Baba Y 

PROVIDER: S-EPMC8858464 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature