Additional insights into the organization of transcriptional regulatory modules based on a 3D model of the Saccharomyces cerevisiae genome.

ABSTRACT:

Objectives

Transcriptional regulatory modules are usually modelled via a network, in which nodes correspond to genes and edges correspond to regulatory associations between them. In the model yeast Saccharomyces cerevisiae, the topological properties of such a network are well-described (distribution of degrees, hierarchical levels, organization in network motifs, etc.). To go further on this, our aim was to search for additional information resulting from the new combination of classical representations of transcriptional regulatory networks with more realistic models of the spatial organization of S. cerevisiae genome in the nucleus.

Results

Taking advantage of independent studies with high-quality datasets, i.e. lists of target genes for specific transcription factors and

SUBMITTER: Poinsignon T 

PROVIDER: S-EPMC8858486 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature