Insulin resistance induced by de novo pathway-generated C16-ceramide is associated with type 2 diabetes in an obese population.

ABSTRACT:

Background

Obesity and diabetes are two chronic metabolic diseases whose prevalence is increasing at an alarming rate globally. A close association between obesity, diabetes, and insulin resistance has been identified, and many studies have pinpointed obesity as a causal risk factor for insulin resistance. However, the mechanism underlying this association is not entirely understood. In the past decade, ceramides have gained attention due to their accumulation in certain tissues and their suggested role in initiating insulin resistance. This study aims to determine the association of specific ceramides and their major metabolizing enzymes with obesity-associated insulin resistance.

Methods

The samples comprised subcutaneous adipose tissues collected from three cohorts: lean

SUBMITTER: Chathoth S 

PROVIDER: S-EPMC8858530 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature