Self-oxygenation mesoporous MnO₂ nanoparticles with ultra-high drug loading capacity for targeted arteriosclerosis therapy.

ABSTRACT: Atherosclerosis (AS) is a leading cause of vascular diseases that severely threats the human health due to the lack of efficient therapeutic methods. During the development and progress of AS, macrophages play critical roles, which are polarized into pro-inflammatory M1 phenotype to excrete abundant cytokines and overproduce reactive oxygen species (ROS), and take up excess amount of lipid to form foam cells. In this work, we developed a MnO₂-based nanomedicine to re-educate macrophages for targeting AS therapy. The MnO₂ was one-pot synthesized under mild condition, showing intrinsic catalase-mimic activity for self-oxygenation by using endogenous H₂O₂ as substrate. Moreover, the mesoporous structure as well as the abundant metal coordination sit

SUBMITTER: Sun W 

PROVIDER: S-EPMC8858544 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature