Osteomodulin attenuates smooth muscle cell osteogenic transition in vascular calcification.

ABSTRACT:

Rationale

Vascular calcification is a prominent feature of late-stage diabetes, renal and cardiovascular disease (CVD), and has been linked to adverse events. Recent studies in patients reported that plasma levels of osteomodulin (OMD), a proteoglycan involved in bone mineralisation, associate with diabetes and CVD. We hypothesised that OMD could be implicated in these diseases via vascular calcification as a common underlying factor and aimed to investigate its role in this context.

Methods and results

In patients with chronic kidney disease, plasma OMD levels correlated with markers of inflammation and bone turnover, with the protein present in calcified arterial media. Plasma OMD also associated with cardiac calcification and the protein was detected in calcified valve le

SUBMITTER: Skenteris NT 

PROVIDER: S-EPMC8858609 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature