Associations between systemic health and retinal nerve fibre layer thickness in preterm infants at 36 weeks postmenstrual age.

ABSTRACT:

Background/aims

Neonatal insults from systemic diseases have been implicated in the pathway of impaired neurodevelopment in preterm infants. We aimed to investigate the associations between systemic health factors and retinal nerve fibre layer (RNFL) thickness in preterm infants.

Methods

We prospectively enrolled infants and imaged both eyes at 36±1 weeks postmenstrual age (PMA) using a hand-held optical coherence tomography system at the bedside in the Duke intensive care nurseries. We evaluated associations between RNFL thickness and 29 systemic health factors using univariable and multivariable regression models.

Results

83 infants with RNFL thickness measures were included in this study. Based on the multivariable model, RNFL thickness was positively associated wi

SUBMITTER: Shen LL 

PROVIDER: S-EPMC8858642 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature