Development of a rational framework for the therapeutic efficacy of fecal microbiota transplantation for calf diarrhea treatment.

ABSTRACT:

Background

Establishing fecal microbiota transplantation (FMT) to prevent multifactorial diarrhea in calves is challenging because of the differences in farm management practices, the lack of optimal donors, and recipient selection. In this study, the underlying factors of successful and unsuccessful FMT treatment cases are elucidated, and the potential markers for predicting successful FMT are identified using fecal metagenomics via 16S rRNA gene sequencing, fecal metabolomics via capillary electrophoresis time-of-flight mass spectrometry, and machine learning approaches.

Results

Specifically, 20 FMT treatment cases, in which feces from healthy donors were intrarectally transferred into recipient diarrheal calves, were conducted with a success rate of 70%. Selenomonas was i

SUBMITTER: Islam J 

PROVIDER: S-EPMC8858662 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature