Pharmacokinetics of Esomeprazole in Critically Ill Patients.

ABSTRACT:

Background

Esomeprazole, a potent proton pump inhibitor (PPI), is widely used for the prevention of stress ulcers in intensive care unit (ICU) patients.

Objective

This study investigates the pharmacokinetics (PK) of esomeprazole in critically ill patients.

Methods

The study included eligible adult ICU patients who received endotracheal intubation assisted mechanical ventilation for more than 48 h and had at least an extra risk factor for stress ulcers. All enrolled patients received once-daily intravenous (IV) esomeprazole 40 mg. After the first dose of esomeprazole was administrated, serial blood samples were collected at 3, 5, 15, 30 min and 1, 2, 4, 6, 8, and 10 h. The total sample concentrations of esomeprazole were measured by UPLC-MS/MS. Esomeprazole PK paramete

SUBMITTER: Xu Y 

PROVIDER: S-EPMC8858832 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature