Circular RNA as a Potential Biomarker for Forensic Age Prediction.

ABSTRACT: In forensic science, accurate estimation of the age of a victim or suspect can facilitate the investigators to narrow a search and aid in solving a crime. Aging is a complex process associated with various molecular regulations on DNA or RNA levels. Recent studies have shown that circular RNAs (circRNAs) upregulate globally during aging in multiple organisms such as mice and C.elegans because of their ability to resist degradation by exoribonucleases. In the current study, we attempted to investigate circRNAs' potential capability of age prediction. Here, we identified more than 40,000 circRNAs in the blood of thirteen Chinese unrelated healthy individuals with ages of 20-62 years according to their circRNA-seq profiles. Three methods were applied to select age-related circRNA candi

SUBMITTER: Wang J 

PROVIDER: S-EPMC8858837 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature