Yap-Sox9 signaling determines hepatocyte plasticity and lineage-specific hepatocarcinogenesis.

ABSTRACT:

Background & aims

Primary liver tumors comprise distinct subtypes. A subset of intrahepatic cholangiocarcinoma (iCCA) can arise from cell fate reprogramming of mature hepatocytes in mouse models. However, the underpinning of cell fate plasticity during hepatocarcinogenesis is still poorly understood, hampering therapeutic development for primary liver cancer. As YAP activation induces liver tumor formation and cell fate plasticity, we investigated the role of Sox9, a transcription factor downstream of Yap activation that is expressed in biliary epithelial cells (BECs), in Yap-induced cell fate plasticity during hepatocarcinogenesis.

Methods

To evaluate the function of Sox9 in YAP-induced hepatocarcinogenesis in vivo, we used several genetic mouse models of inducible hepatocy

SUBMITTER: Liu Y 

PROVIDER: S-EPMC8858854 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature