Stool microbiota are superior to saliva in distinguishing cirrhosis and hepatic encephalopathy using machine learning.

ABSTRACT:

Background & aims

Saliva and stool microbiota are altered in cirrhosis. Since stool is logistically difficult to collect compared to saliva, it is important to determine their relative diagnostic and prognostic capabilities. We aimed to determine the ability of stool vs. saliva microbiota to differentiate between groups based on disease severity using machine learning (ML).

Methods

Controls and outpatients with cirrhosis underwent saliva and stool microbiome analysis. Controls vs. cirrhosis and within cirrhosis (based on hepatic encephalopathy [HE], proton pump inhibitor [PPI] and rifaximin use) were classified using 4 ML techniques (random forest [RF], support vector machine, logistic regression, and gradient boosting) with AUC comparisons for stool, saliva or both sample t

SUBMITTER: Saboo K 

PROVIDER: S-EPMC8858861 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature