Characterizing Sensitive Cardiac Substructure Excursion Due to Respiration.

ABSTRACT:

Purpose

Whole-heart dose metrics are not as strongly linked to late cardiac morbidities as radiation doses to individual cardiac substructures. Our aim was to characterize the excursion and dosimetric variation throughout respiration of sensitive cardiac substructures for future robust safety margin design.

Methods and materials

Eleven patients with cancer treatments in the thorax underwent 4-phase noncontrast 4-dimensional computed tomography (4DCT) with T2-weighted magnetic resonance imaging in end-exhale. The end-exhale phase of the 4DCT was rigidly registered with the magnetic resonance imaging and refined with an assisted alignment surrounding the heart from which 13 substructures (chambers, great vessels, coronary arteries, etc) were contoured by a radiation oncologist

SUBMITTER: Miller CR 

PROVIDER: S-EPMC8858867 | biostudies-literature | 2022 May-Jun

REPOSITORIES: biostudies-literature