Profiling of extracellular vesicle-bound miRNA to identify candidate biomarkers of chronic alcohol drinking in nonhuman primates.

ABSTRACT:

Background

Long-term alcohol drinking is associated with numerous health complications including susceptibility to infection, cancer, and organ damage. However, due to the complex nature of human drinking behavior, it has been challenging to identify reliable biomarkers of alcohol drinking behavior prior to signs of overt organ damage. Recently, extracellular vesicle-bound microRNAs (EV-miRNAs) have been found to be consistent biomarkers of conditions that include cancer and liver disease.

Methods

In this study, we profiled the plasma EV-miRNA content by miRNA-Seq from 80 nonhuman primates after 12 months of voluntary alcohol drinking.

Results

We identified a list of up- and downregulated EV-miRNA candidate biomarkers of heavy drinking and those positively correlated

SUBMITTER: Lewis SA 

PROVIDER: S-EPMC8858875 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature