Ontology highlight
ABSTRACT:
SUBMITTER: Gomez-Soler M
PROVIDER: S-EPMC8858996 | biostudies-literature | 2022 Mar
REPOSITORIES: biostudies-literature
Gomez-Soler Maricel M Gehring Marina P MP Lechtenberg Bernhard C BC Zapata-Mercado Elmer E Ruelos Alyssa A Matsumoto Mike W MW Hristova Kalina K Pasquale Elena B EB
iScience 20220204 3
The EphA2 receptor tyrosine kinase activates signaling pathways with different, and sometimes opposite, effects in cancer and other pathologies. Thus, highly specific and potent biased ligands that differentially control EphA2 signaling responses could be therapeutically valuable. Here, we use EphA2-specific monomeric peptides to engineer dimeric ligands with three different geometric configurations to combine a potential ability to differentially modulate EphA2 signaling responses with the high ...[more]