Circulating α-Klotho Levels in Relation to Cardiovascular Diseases: A Mendelian Randomization Study.

ABSTRACT:

Background

Several studies have reported a protective role of circulating α-Klotho on cardiovascular diseases (CVD); however, the causality remains unclear. We aim to elucidate whether genetically predicted circulating α-Klotho levels were causally associated with the risk of coronary artery disease (CAD), atrial fibrillation (AF), heart failure (HF), stroke, ischemic stroke (IS), and IS subtypes.

Methods

A two-sample Mendelian randomization (MR) study was designed, with 5 single-nucleotide polymorphisms associated with circulating α-Klotho levels utilized as instrumental variables. MR estimates on each CVD outcome derived from the fixed-effects inverse-variance weighted (IVW) approach in different data sources were combined by the fixed-effects meta-analysis approach, compl

SUBMITTER: Sun X 

PROVIDER: S-EPMC8859151 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature