Structural and Functional Diversity of Animal Toxins Interacting With GPCRs.

ABSTRACT: Peptide toxins from venoms have undergone a long evolutionary process allowing host defense or prey capture and making them highly selective and potent for their target. This has resulted in the emergence of a large panel of toxins from a wide diversity of species, with varied structures and multiple associated biological functions. In this way, animal toxins constitute an inexhaustible reservoir of druggable molecules due to their interesting pharmacological properties. One of the most interesting classes of therapeutic targets is the G-protein coupled receptors (GPCRs). GPCRs represent the largest family of membrane receptors in mammals with approximately 800 different members. They are involved in almost all biological functions and are the target of almost 30% of drugs currently on the

SUBMITTER: Van Baelen AC 

PROVIDER: S-EPMC8859281 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature