Repressive Interactions Between Transcription Factors Separate Different Embryonic Ectodermal Domains.

ABSTRACT: The embryonic ectoderm is composed of four domains: neural plate, neural crest, pre-placodal region (PPR) and epidermis. Their formation is initiated during early gastrulation by dorsal-ventral and anterior-posterior gradients of signaling factors that first divide the embryonic ectoderm into neural and non-neural domains. Next, the neural crest and PPR domains arise, either via differential competence of the neural and non-neural ectoderm (binary competence model) or via interactions between the neural and non-neural ectoderm tissues to produce an intermediate neural border zone (NB) (border state model) that subsequently separates into neural crest and PPR. Many previous gain- and loss-of-function experiments demonstrate that numerous TFs are expressed in initially overlapp

SUBMITTER: Klein SL 

PROVIDER: S-EPMC8859430 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature