Enterocolitis Is a Risk Factor for Bowel Perforation in Neonates With Hirschsprung's Disease: A Retrospective Multicenter Study.

ABSTRACT:

Background and aim

We evaluated the clinical features of neonatal Hirschsprung's disease (HD)-associated bowel perforation (perforated HD) and investigated risk factors related to it.

Methods

We retrospectively collected clinical data of neonates (<1 month of age) with perforated HD from multicenters in China from January 2006 to December 2019. A total of 142 patients (6.7%) with perforated HD were enrolled in the study. A 1:2 matching method was used to compare the clinical information of HD patients with and without bowel perforation during the neonatal period. The risk factors for bowel perforation were identified using univariate and multivariate logistic risk regression analyses.

Results

Perforation site was present in the proximal ganglionic bowel in 101 (71.1%)

SUBMITTER: Zhu T 

PROVIDER: S-EPMC8859433 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature