Non-invasive peripheral vascular function, incident cardiovascular disease, and mortality in the general population.

ABSTRACT:

Aims

Evidence suggests that peripheral vascular function is related to cardiovascular disease (CVD) and mortality. We evaluated the associations of non-invasive measures of flow-mediated dilatation and peripheral arterial tonometry with incident CVD and mortality.

Methods and results

In a post-hoc analysis of the community-based Gutenberg Health Study, median age 55 years (25th/75th percentile 46/65) and 49.5% women, we measured brachial artery flow-mediated dilatation (N=12 599) and fingertip peripheral arterial tonometry (N=11 125). After a follow-up of up to 11.7 years, we observed 595 incident CVD events, 106 cardiac deaths, and 860 deaths in total. Survival curves showed decreased event-free survival with higher mean brachial artery diameter and baseline pulse amplitude

SUBMITTER: Schnabel RB 

PROVIDER: S-EPMC8859627 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature