Rituximab in patients with acute ST-elevation myocardial infarction: an experimental medicine safety study.

ABSTRACT:

Aims

In pre-clinical models of acute myocardial infarction (MI), mature B cells mobilize inflammatory monocytes into the heart, leading to increased infarct size and deterioration of cardiac function, whilst anti-CD20 antibody-mediated depletion of B cells limits myocardial injury and improves cardiac function. Rituximab is a monoclonal anti-CD20 antibody targeted against human B cells. However, its use in cardiovascular disease is untested and is currently contraindicated. Therefore, we assessed the safety, feasibility, and pharmacodynamic effect of rituximab given to patients with acute ST-elevation MI (STEMI).

Methods and results

Rituximab in patients with acute ST-elevation myocardial infarction (RITA-MI) was a prospective, open-label, dose-escalation, single-arm, phase

SUBMITTER: Zhao TX 

PROVIDER: S-EPMC8859640 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature