Pharmacological inhibition of acetylcholine-regulated potassium current (I _K,ACh) prevents atrial arrhythmogenic changes in a rat model of repetitive obstructive respiratory events.

ABSTRACT:

Background

In obstructive sleep apnea (OSA), intermittent hypoxemia and intrathoracic pressure fluctuations may increase atrial fibrillation (AF) susceptibility by cholinergic activation.

Objective

To investigate short-term atrial electrophysiological consequences of obstructive respiratory events, simulated by intermittent negative upper airway pressure (INAP), and the role of atrial acetylcholine-regulated potassium current (I _K,ACh) activated by the M₂ receptor.

Methods

In sedated (2% isoflurane), spontaneously breathing rats, INAP was applied noninvasively by a negative pressure device for 1 minute, followed by a resting period of 4 minutes. INAP was applied repeatedly throughout 70 minutes, followed by a 2-hour recovery period. Atrial

SUBMITTER: Linz B 

PROVIDER: S-EPMC8859790 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature