Epigenetic regulation of inflammation by microRNAs in post-infectious bronchiolitis obliterans.

ABSTRACT:

Objectives

Post-infectious bronchiolitis obliterans (PiBO) is a rare, chronic disease initiated by severe infection and followed by perpetuating inflammation and obliteration of the small airways. MicroRNAs (miRNAs) have been proposed to play a central role as epigenetic regulators, which control resolution and prevent the uncontrolled progress of inflammation. The aim of this study was to define biomarkers on the level of post-transcriptional gene regulation in order to characterise PiBO.

Methods

A total of 39 patients with well-defined PiBO and 31 controls from two centres, Barcelona, Spain, and Frankfurt, Germany, were analysed by next-generation sequencing (NGS). The evaluation of the biological targets of the miRNAs was performed by pathway enrichment analysis and prote

SUBMITTER: Duecker RP 

PROVIDER: S-EPMC8859819 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature