Genetically Determined Circulating Levels of Cytokines and the Risk of Rheumatoid Arthritis.

ABSTRACT: Background: Accumulation of inflammatory leukocytes in articular tissues is the hallmark feature of rheumatoid arthritis (RA). Increasing evidence from observational studies has suggested that several cytokines may be involved in the development of RA. However, traditional observational studies are susceptible to bias from confounding and reverse causation; therefore, the potential causal relationships of individual cytokines with the risk of RA remain elusive. Objective: In this study, we evaluated whether genetically determined circulating levels of cytokines were associated with the risk of RA by performing Mendelian randomization (MR). Methods: We identified single nucleotide polymorphisms (SNPs) associated with circulating levels of cytokines and growth factors fr

SUBMITTER: Qian Y 

PROVIDER: S-EPMC8859847 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature