Sex hormones, adiposity, and metabolic traits in men and women: a Mendelian randomisation study.

ABSTRACT:

Objective

Epidemiological and clinical studies have highlighted important roles for sex hormones in the regulation of fat distribution and systemic metabolism. We investigated the bidirectional associations between bioavailable serum testosterone (BioT) in both sexes and oestradiol (E2) in men and adiposity and metabolic traits using Mendelian randomisation (MR).

Design and methods

As genetic instruments for sex hormones, we selected all the genome-wide significant, independent signals from a genome-wide association studies (GWAS) in up to 425 097 European ancestry UK Biobank participants. European population-specific, summary-level data for adiposity, metabolic, and blood pressure traits were obtained from the largest publicly available GWAS. Sex-specific, two-sample MR ana

SUBMITTER: Loh NY 

PROVIDER: S-EPMC8859921 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature