Sustained Antibody-Dependent NK Cell Functions in Mild COVID-19 Outpatients During Convalescence.

ABSTRACT: The coronavirus disease 2019 (COVID19) pandemic has left researchers scrambling to identify the humoral immune correlates of protection from COVID-19. To date, the antibody mediated correlates of virus neutralization have been extensively studied. However, the extent that non-neutralizing functions contribute to anti-viral responses are ill defined. In this study, we profiled the anti-spike antibody subtype/subclass responses, along with neutralization and antibody-dependent natural killer cell functions in 83 blood samples collected between 4 and 201 days post-symptoms onset from a cohort of COVID-19 outpatients. We observed heterogeneous humoral responses against the acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein. Overall, anti-spike profiles were characterized by a

SUBMITTER: Fuentes-Villalobos F 

PROVIDER: S-EPMC8859986 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature