Integrase Strand Transfer Inhibitor Use and Cancer Incidence in a Large Cohort Setting.

ABSTRACT:

Background

Limited data exist examining the association between incident cancer and cumulative integrase inhibitor (INSTI) exposure.

Methods

Participants were followed from baseline (latest of local cohort enrollment or January 1, 2012) until the earliest of first cancer, final follow-up, or December 31, 2019. Negative binomial regression was used to assess associations between cancer incidence and time-updated cumulative INSTI exposure, lagged by 6 months.

Results

Of 29 340 individuals, 74% were male, 24% were antiretroviral treatment (ART)-naive, and median baseline age was 44 years (interquartile range [IQR], 36-51). Overall, 13 950 (48%) individuals started an INSTI during follow-up. During 160 657 person-years of follow-up ([PYFU] median 6.2; IQR, 3.9-7.5), there

SUBMITTER: Greenberg L 

PROVIDER: S-EPMC8860165 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature