RNA-mediated immunotherapy regulating tumor immune microenvironment: next wave of cancer therapeutics.

ABSTRACT: Accumulating research suggests that the tumor immune microenvironment (TIME) plays an essential role in regulation of tumor growth and metastasis. The cellular and molecular nature of the TIME influences cancer progression and metastasis by altering the ratio of immune- suppressive versus cytotoxic responses in the vicinity of the tumor. Targeting or activating the TIME components show a promising therapeutic avenue to combat cancer. The success of immunotherapy is both astounding and unsatisfactory in the clinic. Advancements in RNA-based technology have improved understanding of the complexity and diversity of the TIME and its effects on therapy. TIME-related RNA or RNA regulators could be promising targets for anticancer immunotherapy. In this review, we discuss the available RNA-based

SUBMITTER: Pandey PR 

PROVIDER: S-EPMC8860277 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature