Mitochondrial perturbation reduces susceptibility to xenobiotics through altered efflux in Candida albicans.

ABSTRACT: Candida albicans is a leading human fungal pathogen, which can cause superficial infections or life-threatening systemic disease in immunocompromised individuals. The ability to transition between yeast and filamentous forms is a major virulence trait of C. albicans, and a key regulator of this morphogenetic transition is the molecular chaperone Hsp90. To explore the mechanisms governing C. albicans morphogenesis in response to Hsp90 inhibition, we performed a functional genomic screen using the gene replacement and conditional expression collection to identify mutants that are defective in filamentation in response to the Hsp90 inhibitor, geldanamycin. We found that transcriptional repression of genes involved in mitochondrial function blocked filamentous growth in response to the concent

SUBMITTER: Hossain S 

PROVIDER: S-EPMC8860387 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature