<i>Anopheles</i> salivary antigens as serological biomarkers of vector exposure and malaria transmission: A systematic review with multilevel modelling.

ABSTRACT:

Background

Entomological surveillance for malaria is inherently resource-intensive and produces crude population-level measures of vector exposure which are insensitive in low-transmission settings. Antibodies against Anopheles salivary proteins measured at the individual level may serve as proxy biomarkers for vector exposure and malaria transmission, but their relationship is yet to be quantified.

Methods

A systematic review of studies measuring antibodies against Anopheles salivary antigens (PROSPERO: CRD42020185449). Multilevel modelling (to account for multiple study-specific observations [level 1], nested within study [level 2], and study nested within country [level 3]) estimated associations between seroprevalence with Anopheles human biting rate

SUBMITTER: Kearney EA 

PROVIDER: S-EPMC8860437 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature