Modulated termination of non-coding transcription partakes in the regulation of gene expression.

ABSTRACT: Pervasive transcription is a universal phenomenon leading to the production of a plethora of non-coding RNAs. If left uncontrolled, pervasive transcription can be harmful for genome expression and stability. However, non-coding transcription can also play important regulatory roles, for instance by promoting the repression of specific genes by a mechanism of transcriptional interference. The efficiency of transcription termination can strongly influence the regulatory capacity of non-coding transcription events, yet very little is known about the mechanisms modulating the termination of non-coding transcription in response to environmental cues. Here, we address this question by investigating the mechanisms that regulate the activity of the main actor in termination of non-coding transcrip

SUBMITTER: Haidara N 

PROVIDER: S-EPMC8860598 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature