Dual Function of a in vivo Albumin-Labeling Tracer for Assessment of Blood Perfusion and Vascular Permeability in Peripheral Arterial Disease by PET.

ABSTRACT:

Background

Peripheral arterial disease (PAD) leads to tissue ischemia in the extremities. Enhanced vascular permeability plays a critical role in targeted delivery of drugs for effective therapeutic angiogenesis and resultant blood perfusion recovery. However, optimal tracers for evaluating this process in PAD patients are lacking. At this time, we employed a novel in vivo albumin-labeling tracer of dual function, termed as ¹⁸F-NEB, to assess blood perfusion as well as vascular permeability by positron emission tomography (PET).

Methods and results

After successful establishment of mouse hindlimb ischemia (HI) model, static PET imaging was performed 15 min and 2 h post injection (p.i.) of ¹⁸F-NEB at 1, 3, 5, 7, 10 and 14 days post-surgery respect

SUBMITTER: Sun Z 

PROVIDER: S-EPMC8860820 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature