Fecal Implants From App ^NL-G-F and App ^NL-G-F/E4 Donor Mice Sufficient to Induce Behavioral Phenotypes in Germ-Free Mice.

ABSTRACT: The gut microbiome and the gut brain axis are potential determinants of Alzheimer's disease (AD) etiology or severity and gut microbiota might coordinate with the gut-brain axis to regulate behavioral phenotypes in AD mouse models. Using 6-month-old human amyloid precursor protein (hAPP) knock-in (KI) mice, which contain the Swedish and Iberian mutations [APP NL-F (App ^NL-F)] or the Arctic mutation as third mutation [APP NL-G-F (App ^NL-G-F)], behavioral and cognitive performance is associated with the gut microbiome and APP genotype modulates this association. In this study, we determined the feasibility of behavioral testing of mice in a biosafety cabinet and whether stool from 6-month-old App ^NL-G-F mice or App ^NL-G-F

SUBMITTER: Kundu P 

PROVIDER: S-EPMC8860839 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature